Certain adverse clinical events, some life-threatening, are a direct consequence of physical dependence to XANAX. These include a spectrum of withdrawal.
Fluvoxamine — Coadministration of fluvoxamine approximay doubled the maximum plasma concentration of alprazolam, decreased clearance by 49%, increased half-life by 71%, and decreased measured psychomotor performance.
Cimetidine — Coadministration of cimetidine increased the maximum plasma concentration of alprazolam by 86%, decreased clearance by 42%, and increased half-life by 16%
It is recommended that the dosage be limited to the smallest effective dose to preclude the development of ataxia or oversedation which may be a particular problem in elderly or debilitated patients.
The ultimate guide to benzodiazepine withdrawal symptom relief with tips to soothe Benzos such as Xanax, Ativan, and Valium are meant for short-term relief.
Benzos act as a depressant. That means the drug slows down functions of the body and dulls chemical receptors in the brain. When benzodiazepine use stops, “calming” chemicals benzos provide are no longer present. After long-term abuse, individuals deal with a range of difficult emotions. No longer able to calm themselves without medication, users may exhibit intial benzodiazepine withdrawal symptoms like obsessive, irrational, raging, hyperactive or hysterical behavior.
When an individual dependent on Xanax then attempts to stop taking the drug, the brain needs some time to return to previous levels of functioning. The emotional symptoms of benzodiazepine withdrawal can be powerful, as anxiety, panic, and paranoia may increase with the drug's removal from the body.
Protracted withdrawal can last for several weeks, months, or even years without being addressed by a mental health professional.
Xanax should not be stopped suddenly, or “cold turkey,” and vital signs like blood pressure, heart rate, respiration levels, and temperature need to be closely monitored during its removal from the body.
Xanax is a brand name of alprazolam, a prescription drug primarily used to treat anxiety disorders. Alprazolam may also be prescribed to treat anxiety.
Medical complications experienced during withdrawal can include the following, according to the Center for Substance Abuse Treatment :
The best and safest option is for individuals to undergo medical detox in a professional facility. In cases of benzodiazepine withdrawal, medical detox is always recommended.